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Linzixuan (Rhoda) Zhang holding the medal she won in the 2024 Collegiate Inventors Competition

Rhoda Zhang Wins 2024 Collegiate Inventors Competition

MIT News

Graduate student Linzixuan (Rhoda) Zhang has won the 2024 Collegiate Inventors Competition in both the Graduate and People's Choice categories. With advisors Robert Langer and Ana Jaklenec, Zhang and KI postdoc Xin Yang are developing metal-organic frameworks and other safe, sustainable nutrient stabilizing materials to address global micronutrient deficiencies. They are also launching MOFe™ Coffee, the first iron-fortified coffee.

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Age of Senescence

MIT Biology

The Hemann and Walker labs previously discovered that the compound JH-RE-06 enhanced the tumor-shrinking effects of DNA-damaging chemotherapies. While they expected JH-RE-06 to amplify programmed cell death induced by DNA damage, two studies appearing in PNAS showed that JH-RE-06, or genetically ablating the pathway targeted by JH-RE-06, instead puts tumor cells in a permanently dormant state known as senescence. Because senescent cells are often cleared by immune cells, these findings suggest a complementary approach to traditional chemotherapies. 

Growing Evidence

bioRxiv

In a biorxiv paper posted two days before Amon’s passing, researchers in her group, with collaborators in the Lees and Yilmaz labs, illuminate the relationship between stem cell size and function, and tissue aging. Despite great variability in cell size and shape between tissues, stem cells are invariably small. The Amon lab’s studies present evidence that small size is critical for hematopoietic stem cell function. Analyses of these cells also showed that they get progressively bigger with organismal aging, and that the larger stem cells are less functional. These findings suggest that large size causes stem cell function to decline during aging. This work was partly supported by the MIT Stem Cell Initiative.

Freeze Frame

Structure

The KI’s Robert A. Swanson (1969) Biotechnology Center regularly adapts and evolves specialized techniques and technologies. In a cover-winning Structure paper, researchers from the Peterson (1957) Nanotechnology Materials Core Facility have developed a new 3D imaging workflow that integrates three imaging approaches to visualize the same sample at cryogenic temperature at different scales, providing a unique view into features of cell structure. Demonstrated in yeast, the process could be used for large-scale studies of frozen specimens in healthy, diseased, and therapeutic conditions. Currently, the research team is the only one in the US with the specific technological capabilities—volume cryo-focused ion beam scanning electron microscopy, cryo-fluorescence confocal microscopy, and transmission cryo-electron tomography—to run this entire workflow.

Vaccine Around Town

Spectrum

Spectrum showcases two cancer- and pandemic-relevant research projects in their COVID-19-themed fall issue. Love Lab researchers are optimizing their rapid vaccine development platform to accelerate the advancement and production of COVID-19 vaccine candidates. The Chen Lab is exploring vaccine enhancement agents to improve immune response and decrease inflammation.

Positive Signals

PR Newswire

Results were recently announced from a Phase 2 trial, launched with support from the Bridge Project, to test a synergistic drug combination identified in the Yaffe lab. Patients with metastatic castration-resistant prostate cancer were assigned one of three different dosing schedules; the majority saw improved or stable disease in all three groups. Additionally, the team has identified a biomarker associated with therapeutic response.

Companion Diagnostics Approved

MIT Koch Institute

Foundation Medicine, co-founded by KI member Eric Lander, has announced two FDA approvals for two of its diagnostic tools—a blood-based biopsy to identify patients with BRCA1, BRCA2, and/or ATM alterations in metastatic castration-resistant prostate cancer, and a genomic test to seek out patients who express the NTRK1/2/3 gene fusions in a range of solid tumors.

Remembering Angelika 

MIT News

The Koch Institute mourns the loss and honors the life of Angelika Amon, professor of biology and Kathleen and Curtis (1963) Marble Professor of Cancer Research, who died on October 29, 2020, at age 53, following a two-and-a-half-year battle with ovarian cancer. A pioneer in the study of aneuploidy, Amon made profound contributions to our understanding of the fundamental biology of the cell and the role of chromosome mis-segregation in cancer. Throughout her career, she inspired others with her characteristic perseverance, curiosity, and enthusiasm for discovery, and her broad interest in the world around her. Amon was a dedicated mentor and a fearless advocate for science and the rights of women and minorities. Her deep network of scientific collaborations and friendships reflects the light and passion she brought to every endeavor, both in and beyond the laboratory. Notes Koch Institute director Tyler Jacks, “Angelika was a force of nature... and has made an incredible impact on the world—one that will last long into the future.”

MIT News Obituary | MIT Faculty ResolutionThe Scientist | The Boston Globe | Science | Developmental Cell | Cancer CellResearch Institute of Molecular Pathology | Journal of Cell Science 

Convergence by the Book

MIT News

Congratulations to KI member Susan Hockfield, MIT President Emerita, whose book The Age of Living Machines has been honored with a 2020 Science Communication Award from the American Institute of Physics. The awards recognize writers' efforts to improve the general public's appreciation of the physical sciences, astronomy, math, and related scientific fields. Hockfield's narrative celebrates the people and science stories behind the “convergence revolution."

Introducing the 2020-2021 Convergence Scholars

MIT Koch Institute

The Marble Center for Cancer Nanomedicine and the MIT Center for Precision Cancer Medicine are pleased to announce the 2020-2021 class of Convergence Scholars. The Convergence Scholars Program (CSP) provides postdoctoral trainees with opportunities to further their experiences and skills beyond the research laboratory. Scholars will learn more about science project development, policy, technology transfer, education and outreach, business and finances, industry, and the clinic.

Jacks to Step Down

MIT News

Tyler Jacks will step down from his role as director, pending selection of his successor. Jacks, a David H. Koch Professor of Biology and Daniel K. Ludwig Scholar, has served as director for more than 19 years, first for the MIT Center for Cancer Research (CCR) and then for its successor, the Koch Institute.

“Tyler Jacks turned the compelling idea to accelerate progress against cancer by bringing together fundamental biology, engineering know-how, and clinical expertise, into the intensively collaborative environment that is now the Koch Institute for Integrative Cancer Research,” says Susan Hockfield who, as then-MIT President, strongly supported the Koch Institute’s formation. “His extraordinary leadership has amplified the original idea into a paradigm-changing approach to cancer, which now serves as a model for research centers around the world.”

During his tenure, Jacks and his colleagues shepherded the creation of numerous centers and programs to support cross-disciplinary research in high-impact areas and expedite translation from the bench to the clinic. Institude Professor Phillip Sharp, a Nobel laureate and himself a former director of the CCR, will lead the search for the next director of the Koch Institute, with guidance from noted leaders in MIT’s cancer research community.

After Jacks steps down, he will continue his research in the areas of cancer genetics and immune-oncology and his teaching, while also stewarding the Bridge Project into its second decade.