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Linzixuan (Rhoda) Zhang holding the medal she won in the 2024 Collegiate Inventors Competition

Rhoda Zhang Wins 2024 Collegiate Inventors Competition

MIT News

Graduate student Linzixuan (Rhoda) Zhang has won the 2024 Collegiate Inventors Competition in both the Graduate and People's Choice categories. With advisors Robert Langer and Ana Jaklenec, Zhang and KI postdoc Xin Yang are developing metal-organic frameworks and other safe, sustainable nutrient stabilizing materials to address global micronutrient deficiencies. They are also launching MOFe™ Coffee, the first iron-fortified coffee.

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How sweet it is

Boston Globe

Bob Langer now has a chocolate named after him. Ben and Bill’s Chocolate Emporium in Falmouth has introduced Dr. Bob's Dark Chocolate Maple Syrup Cream, inspired by his love of maple. Bob is a longtime regular of the shop — its old-timey feel and candy-filled shelves remind Bob of his favorite childhood candy store in Albany.  

Meet the 2024 Amon Award Winners

MIT Koch Institute

The Koch Institute at MIT is pleased to announce the winners of the 2024 Angelika Amon Young Scientist Award, Anna Uzonyi and Lukas Teoman Henneberg. The prize was established in 2021 to recognize graduate students in the life sciences or biomedical research from institutions outside the United States who embody Dr. Amon’s infectious enthusiasm for discovery science. 



 

Fast track to healing could spell tumor trouble

MIT News

A new study from the Yilmaz Lab demonstrates the benefits and downside of fasting.

While low-calorie diets and intermittent fasting are known to boost intestinal regeneration and aid recovery from injuries or inflammation, this study, published in Nature, reveals something new: it also leads to a higher risk of cancer in mice. Further studies are needed before forming any conclusion as to whether fasting has a similar effect in humans.

This research was funded in part by the MIT Stem Cell Initiative, the Koch Institute Frontier Research Program via the Kathy and Curt Marble Cancer Research Fund, and the Bridge Project.
 

There's no place like home

MIT Koch Institute

Vander Heiden Lab researchers showed that metastasized cancer cells prefer the nutrient landscape of their home tissue and retain more of their metabolic programming than previously thought. Their results, published in Nature Metabolism, suggest that the metabolic programs developed in a cancer cell’s tissue of origin may limit where it can metastasize.

This study was funded in part by the Lustgarten Foundation, the MIT Center for Precision Cancer Medicine, the Ludwig Center at MIT, and the Emerald Foundation.

Progress for PanTher

PR NewsWire

Following positive initial results, PanTher has received IND clearance to advance their absorbable drug-delivery film for treating pancreatic cancer to the next phase of clinical trials. PanTher’s approaches—based on their signature platform, developed in the Edelman lab with support from the Bridge Project—provide continuous, high-dose treatment of potent therapeutics exclusively at the tumor site.

Keeping it local with immunotherapy

Nature Immunology

A new study from the Irvine and Wittrup labs, published in Nature Immunology, describes a novel immunotherapy approach that delivers and retains cytokines directly in tumors and nearby lymph nodes via a combination of locally administered IL-12 and IL-15, both engineered to target the CD45 receptor.

Unlike other efforts, this approach localizes the effects of cytokines, ensuring that the drugs stay inside the tumor and neighboring lymph nodes to prevent leakage and the severe systemic side effects that accompany it.

Alex Shalek to direct IMES

MIT News

Alex Shalek has been appointed Director of the Institute for Medical Engineering and Sciences (IMES). IMES integrates engineering, science, and medicine to advance and accelerate innovation in human health. Shalek, who is also the J. W. Kieckhefer Professor in the Department of Chemistry, as well as a member of the Koch Institute and the MIT Stem Cell Initiative, began his appointment on August 1.

Recognizing Excellence

MIT News

Highlighting the exceptional expertise and essential research role played by our Robert A. Swanson (1969) Biotechnology Center, members of the Peterson (1957) Nanotechnology Materials Core Facility staff were recognized with the 2024 MIT Excellence Award in the Innovative Solutions category. Congratulations to Margaret (Peggy) Bisher, Giovanni de Nola, David Mankus, and Dong Soo Yun!

Primed for success

Harvard-MIT Health Sciences and Technology

Carmen Martin Alonso, 2024 HST graduate, has been awarded a provisional patent for her liquid biopsy priming agents developed in the labs of Sangeeta Bhatia, Chris Love, and the Broad Institute's Viktor Adalsteinsson. Alonso’s priming agents make it easier to detect circulating tumor DNA in blood samples, which could enable earlier cancer diagnosis and help guide treatment.   

A SMART way to produce (CAR)T-cells

MIT News

Michael Birnbaum and researchers at the Singapore-MIT Alliance for Research & Technology Centre (SMART) have discovered a way to produce CAR T-cells for the treatment of cancer. The technology, which uses a microfluidic chip roughly the size of a pack of cards, could lower manufacturing costs for cell therapies and enable point-of-care CAR T-cell production in hospitals.