January 28-29, 2019
Biological, chemical, and materials engineers are engaged at the forefront of immunology research. At their disposal is an analytical toolkit honed to solve problems in the petrochemical and materials industries, which share the presence of complex reaction networks, and convective and diffusive molecular transport. Powerful synthetic capabilities have also been crafted: binding proteins can be engineered with effectively arbitrary specificity and affinity, and multifunctional nanoparticles and gels have been designed to interact in highly specific fashions with cells and tissues. Fearless pursuit of knowledge and solutions across disciplinary boundaries characterizes this nascent discipline of immune engineering, synergizing with immunologists and clinicians to put immunotherapy into practice.
Schedule
Day 1: January 28, 2019
7:00-8:10 Registration
8:10-8:15 Introductory Remarks
8:15-9:40 Session I
Moderator: Dane Wittrup | Koch Institute | MIT
Robert Schreiber | Bursky Center for Human Immunology and Immunotherapy Programs | Washington University School of Medicine in St. Louis
Neoantigens and the molecular basis of personalized cancer immunotherapy
Tyler Jacks | Koch Institute for Integrative Cancer Research | MIT
Exploring tumor-immune interactions with genetically engineered cancer models
Poster Presenter
Scott Wilson | University of Chicago
Cathy Wu | Dana-Farber Cancer Institute | Harvard Medical School
Building better personal cancer vaccines
9:40-10:40 Poster Session | Break
10:40-11:55 Session II
Moderator: Tyler Jacks | Koch Institute | MIT
Melody Swartz | University of Chicago
Engineering local lymphangiogenesis for immunomodulation
Darrell Irvine | Koch Institute for Integrative Cancer Research | MIT
Innate immune recognition of glycosylation in nanoparticle vaccines
Stephanie Dougan | Dana-Farber Cancer Institute | Harvard Medical School
Augmenting T cell immunity to poorly immunogenic tumors
12:00-1:30 Lunch Break
1:30-3:20 Session III
Moderator: Darrell Irvine | Koch Institute | MIT
Max Krummel | Bakar ImmunoX Initiative | University of California, San Francisco
Imaging a world beyond checkpoints: Classes of immune systems in vivo
Stefani Spranger | Koch Institute for Integrative Cancer Research | MIT
The role of tumor-resident DC for productive anti-tumor immune responses
Poster Presenter
Noor Momin | MIT
Mikael Pittet | Harvard Medical School | Massachusetts General Hospital
Myeloid cells in cancer
Michael Dustin | Kennedy Institute of Rheumatology | University of Oxford
Delivery of T cell effector function through extracellular vesicles
3:20-4:00 Poster Session | Break
Day 2: January 29, 2019
8:15-9:40 Session IV
Moderator: Michael Birnbaum | Koch Institute | MIT
Jamie Spangler | Johns Hopkins University
Reprogramming anti-cancer immunity through molecular engineering
Bryan Bryson | MIT
Exploiting the macrophage axis in Mycobacterium tuberculosis infection
Poster Presenter
Preeti Sharma | University of Illinois
Facundo Batista | Ragon Institute of MGH, MIT and Harvard
Vaccine evaluation in rapidly produced custom humanized mouse models
9:40-10:30 Poster Session | Break
10:30-11:45 Session V
Moderator: Dane Wittrup | Koch Institute | MIT
Yvonne Chen | University of California, Los Angeles | Parker Institute for Cancer Immunotherapy, Center at UCLA
Engineering smarter and stronger T cells for cancer immunotherapy
Michael Birnbaum | Koch Institute for Integrative Cancer Research | MIT
A repertoire-scale look at T and NK cell recognition
Glenn Dranoff | Novartis Institutes for BioMedical Research
Mechanisms of protective tumor immunity
11:45-1:00 Lunch Break
1:00-2:00 Session VI
Moderator: Stefani Spranger | Koch Institute | MIT
Timothy A. Springer | Harvard Medical School | Boston Children's Hospital
The Milieu Model for TGF-β Activation
Alex Shalek | Institute for Medical Engineering and Science | Koch Institute for Integrative Cancer Research | MIT
Identifying and rationally modulating cellular drivers of enhanced immunity
Poster Presenter
Martin LaFleur | Harvard Medical School
2:00-2:45 Poster Session | Break
2:45-3:35 Session VII
Moderator: Stefani Spranger | Koch Institute | MIT
Diane Mathis | Harvard Medical School
Tissue Tregs
Aviv Regev | Broad Institute | MIT
Cell atlases as roadmaps to understand cancer